Session S20 - Applied Math and Computational Methods and Analysis across the Americas

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Modeling and simulation of adaptive resistance evolution

Pastor E. Pérez Estigarribia

Facultad Politécnica - Universidad Nacional de Asunción, Paraguay   -   This email address is being protected from spambots. You need JavaScript enabled to view it.

Resistance to insecticides (larvicides and / or adulticides) is considered today one of the greatest threats to the control of vector mosquitoes, since its appearance drastically reduces the efficiency of chemical control campaigns and can also disrupt the application of other control methods, such as biological and genetic control. In this work we use a general population model continuous in time with two life phases under selective pressure, simplified through slow manifold theory to simulate various evolution scenarios in mosquito populations, including directional and non-directional (i.e. overdominance and subdominance) selection. In addition, it is illustrated how the level of allelic dominance and the reversibility in the evolution of resistance can increase the effectiveness of chemical control.

Joint work with Pastor E Pérez-Estigarribia (Polytechnic School, National University of Asunción, P.O. Box 2111 SL, San Lorenzo, Paraguay. Electronic address: This email address is being protected from spambots. You need JavaScript enabled to view it.), Pierre-Alexandre Bliman (Sorbonne Université, Université Paris-Diderot SPC, Inria, CNRS, Laboratoire Jacques-Louis Lions, équipe Mamba, 75005 Paris, France. Electronic address: This email address is being protected from spambots. You need JavaScript enabled to view it.) and Christian E Schaerer (Polytechnic School, National University of Asunción, P.O. Box 2111 SL, San Lorenzo, Paraguay. Electronic address: This email address is being protected from spambots. You need JavaScript enabled to view it.).

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